Ask the Experts: Intradiscal Spine Treatment Options – Podcast Episode 7

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• 00:11    Introductions -Dr(s). Furman, Naftulin and Derby
• 03:21    Defining Discogenic Pain. What History and Exam Findings Suggest a Discogenic Pain Etiology?
• 07:00    Introduction Dr. Calodney
• 08:03    What History and Exam Findings Suggest a Discal Pain Source? (continued)
• 11:51    What is the Correlation Between the Finding of a High-intensity Cone on MRI and the Presence of Discogenic Pain?
• 13:06    What is the Role of Discography in the Diagnosis of Discogenic Pain?
• 14:24    What is the Role of Discography in Selecting Between Intradiscal Therapies and Basivertebral Nerve Ablation ?
• 18:45    What is the Role of Analgesic Discography in the Treatment of Discogenic Pain?
• 23:55    When Should Prophylactic Antibiotics Be Used Prior to Intradiscal Procedures?
• 27:44    What is the Optimal Route of Antibiotic Administration?
• 29:40    Are Biomarkers Useful in the Diagnosis of Discogenic Pain?
• 31:57    What is the Role of Discography in Differentiating Between Discogenic and Vertebrogenic Pain Etiologies?
• 35:37    What is the Role of Intradiscal Electrothermal Therapy (IDET) in the Treatment of Discogenic Pain?
• 37:44    What is the role of intradiscal biologic therapies in the treatment of discogenic pain?
• 43:56    What is the Optimal Colume of Injectate When Using Intradiscal Biologic Therapies?
• 45:24    Is There a Role for Targeting Additional Anatomic Structures (Z-joint, Epidural Space, etc.) When Using Biologic Therapies? 
• 48:08    Is There a Role for Other Therapies Such as Intradiscal Ozone and Intradiscal Allogenic Disc Tissue (VIADISC) in the Treatement of Discogenic Pain?
• 53:31    Final Treatment Recommendations from the Experts

Your expert panel for this April 25, 2024 webinar included:

• IPSIS Master Instructor Aaron Calodney, MD; and,
• IPSIS Past President and Founding Member, Richard Derby, MD, and
• IPSIS Membership Committee Chair, Scott Naftulin, DO

The panel was moderated by Michael Furman, MD, MS, Fellowship Director at OSS Health, who also serves on the IPSIS Board as a Member-at-Large.

You can also watch the video of this webinar here.

Episode 7 Show Notes: These are the abstracts referenced by our experts.

• Autologous Bone Marrow Concentrate Intradiscal Injection for the Treatment of Degenerative Disc Disease with Three-Year Follow-up
• Bone Marrow Concentrate and Platelet‐Rich Plasma Differ in Cell Distribution and Interleukin 1 Receptor Antagonist Protein Concentration
• Case Series of Ultrasound-Guided Platelet-Rich Plasma Injections for Sacroiliac Joint Dysfunction
• Clinical Outcomes Following Intradiscal Injections of Higher‐Concentration Platelet‐Rich Plasma in Patients with Chronic Lumbar Discogenic Pain
• Effectiveness of Intradiscal Platelet Rich Plasma for Discogenic Low Back Pain Without Modic Changes: A Randomized Controlled Trial
• Effect of Age on Outcomes After Allogeneic Disc Tissue Supplementation in Patients with Chronic Discogenic Low Back Pain in the VAST Trial
• Evaluation of the Effectiveness of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Chronic Low Back Pain Due to Severe Lumbar Spinal Degeneration: A 12-Month, Open-Label, Prospective Controlled Trial
• Increased Expression of Inflammatory Cytokines and Discogenic Neck Pain
• Injections of Concentrated Bone Marrow Aspirate as Treatment for Discogenic Pain: a Retrospective Analysis
• Insights into Exosome in the Intervertebral Disc: Emerging Role for Disc Homeostasis and Normal Function
• Intradiscal Platelet-Rich Plasma Injection for Discogenic Low Back Pain and Correlation with Platelet Concentration: A Prospective Clinical Trial
• Mesenchymal Stem Cells: Environmentally Responsive Therapeutics for Regenerative Medicine
• Platelet-Rich Plasma-Releasate (PRPr) for the Treatment of Discogenic Low Back Pain Patients: Long-Term Follow-Up Survey
• Potential Role for Stem Cell Regenerative Therapy as a Treatment for Degenerative Disc Disease and Low Back Pain: A Systematic Review
• Preclinical Animal Study and Pilot Clinical Trial of Using Enriched Peripheral Blood-Derived Mononuclear Cells for Intervertebral Disc Degeneration
• Regulatory Roles of Noncoding RNAs in Intervertebral Disc Degeneration as Potential Therapeutic Targets (Review)
• Risks of Intradiscal Orthobiologic Injections: A Review of the Literature and Case Series Presentation
• Safety and Efficacy of Platelet Rich Plasma for Treatment of Lumbar Discogenic Pain: A Prospective, Multicenter, Randomized, Double-blind Study
• Single-Cell Transcriptome Profiling Reveals Multicellular Ecosystem of Nucleus Pulposus during Degeneration Progression
• Stem Cells and Discogenic Back Pain
• Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration
• Structural Organization of the Bone Marrow and its Role in Hematopoiesis
• Systematic Review of Platelet-Rich Plasma for Low Back Pain
• Technical Considerations in Obtaining Platelet Rich Fibrin for Clinical and Periodontal Research
• The Analgesic Efficacy of Intradiscal Injection of Bone Marrow Aspirate Concentrate and Culture-Expanded Bone Marrow Mesenchymal Stromal Cells in Discogenic Pain: A Systematic Review
• The Effect of Intradiscal Platelet-Rich Plasma Injection for Management of Discogenic Lower Back Pain: A Meta-Analysis
• The Safety and Effectiveness of Orthobiologic Injections for Discogenic Chronic Low Back Pain: A Multicenter Prospective, Crossover, Randomized Controlled Trial with 12 Months Follow-up
• VAST Clinical Trial: Safely Supplementing Tissue Lost to Degenerative Disc Disease
  

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